Introduction: Comprehensive health centers, as the most important providers of health services, should be regularly evaluated. The most important dimension of this evaluation is assessment from the perspective of service recipients and their level of satisfaction with the services received. This study aimed to determine the factors affecting patient satisfaction among clients attending comprehensive health centers in Isfahan city.Methods: This descriptive–analytical cross-sectional study was conducted on 185 diabetic patients referring to comprehensive health centers in Isfahan in 2024. Data were collected using a researcher-made patient satisfaction questionnaire. Data analysis was performed using SPSS version 26. Independent t-test and analysis of variance (ANOVA) were used for data analysis. The level of statistical significance was set at p < 0.05.Results: The findings showed that the highest percentage of patients were in the 18–46-year age group, while the lowest percentage belonged to patients aged 65 years and older. A statistically significant relationship was found between gender and educational level with the level of satisfaction among outpatients. However, no statistically significant relationship was observed between the frequency of visits to health centers, employment status, type of insurance, and marital status with patient satisfaction.Conclusion: Given the importance of patient satisfaction with health service delivery, the results of this study can help health system policymakers identify weaknesses and shortcomings, recognize strengths, and utilize existing opportunities to improve the provision of health care services.